Alla Gagarinova

Academic interests

• Systems biology
• Genetic intereactions and chemogenomics;
• Proteomics;
• New antibacterials;
• Host-microbe and microbe-microbe interactions;
• Environmental adaptation and antibiotic resistance.

Brief biography

I completed my Honours BSc degree with High Distinction in Biology and Biochemistry at the University of Toronto in Mississauga, MSc in the Department of Biology at the University of Western Ontario (now Western University, in London, Ontario), and PhD in the Department of Molecular Genetics at the University of Toronto. I completed my postdoctoral research at the University of Saskatchewan and the University of Regina.

At UNB, I use interdisciplinary approaches to investigate bacterial biology, genetic and protein-protein interactions, environmental adaptation, antimicrobial resistance, as well as host-microbe and microbe-microbe interactions.

Our in-house state-of-the-art robotic instrumentation allows large-scale bacterial colony pinning, liquid handling, and high-throughput screening. Additional instrumentation, including mass spectrometers, next-generation sequencers, real-time cell metabolic analysers, and qPCR equipment, is available through collaborators.

Courses taught

• BIOL3013 Advanced Genetics
• BIOL1001 Biological Principles, Part I

Selected research

Gagarinova A, Hosseinia A, Rahmatbakhsh M, Istace Z, Phanse S, Moutaoufik M T, Zilocchi M, Zhang Q, Aoki H, Kim S Y, Aly K, Babu M. (2022). Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli. Nature Communications. 13(1): 4085.

Grishin A, Voth K, Gagarinova A, Cygler M. (2022). Structural biology of the invasion arsenal of Gram-negative bacterial pathogens. The FEBS Journal. 289(6):1385-1427.

Rahmatbakhsh M, Gagarinova A, Babu M. (2021). Bioinformatic analysis of temporal and spatial changes during infection. Frontiers In Genetics, Sec. Systems Biology Archive.

Gagarinova A, Hosseinnia A, Babu M. (2021). Quantitative genetic screens for mapping bacterial pathways and functional networks. Methods in Molecular Biology. 2381: 3-37.